Search results for "PARAINFLUENZA VIRUS"

showing 10 items of 10 documents

A risk-adapted approach to treating respiratory syncytial virus and human parainfluenza virus in allogeneic stem cell transplantation recipients with…

2017

Here we report the applicability of a protocol based on clinical conditions and risk factors (RFs) for managing 35 allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients who developed a total of 52 episodes of respiratory viral infections (RVIs) caused by respiratory syncytial virus (RSV; n=19), human parainfluenza virus (HPIV; n=29), or both (n=4) over a 2-year study period. Risk categories were classified as high risk (cat-1) when the immunodeficiency scoring index was >= 3 and/or >= 3 RFs and/or >= 1 co-infective virus(es) were present; the remaining cases were classified as low risk (cat-0). The presence of two or more signs or symptoms including fever (T>38 degrees C…

AdultMale0301 basic medicinemedicine.medical_specialtyrespiratory syncytial virus030106 microbiologyTonsillitisAdministration OralPilot ProjectsRespiratory Syncytial Virus InfectionsAntiviral Agents03 medical and health scienceschemistry.chemical_compound0302 clinical medicineInternal medicineLower respiratory tract infectionRibavirinmedicineHumansECIL-4allogeneic hematopoietic stem cell transplantationhuman parainfluenza virusProspective Studiesrespiratory viral infectionSinusitisimmunodeficiency scoring indexImmunodeficiencyAgedTransplantationParamyxoviridae InfectionsRespiratory tract infectionsbusiness.industryRibavirinHematopoietic Stem Cell TransplantationMiddle Agedmedicine.diseaseTransplantationHuman Parainfluenza VirusInfectious DiseaseschemistryImmunologyoral ribavirinFemalebusinessStem Cell Transplantation030215 immunology
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H-2-linked murine cytotoxic T cell responses specific for sendai virus-infected cells

1978

CBA (H-2k) mouse-derived lymphochoriomeningitis virus and herpes simplex virus-specific cytotoxic T lymphocytes lyse virus-infected target cells compatible on either the H-2k or H-2D region. In contrast, CBA, C3H and AKR (H-2k) mouse-derived sendai virus-specific cytotoxic T lymphocytes (CTL) fail to lyse H-2D-compatible virus-infected cells. A similar lack of H-2D region-associated lytic activity was found with C57BL/6 and C57BL/10 (H-2b) mice as well as with the recombinants B10.A (2R) [Kb-Db] and B10.A (4R) [Kk-Db]. On the other hand, BALB/c (H-2d) mice and A/J (H-2a) mice do generate H-2Dd-associated sendai virus-specific CTL. These results are in contrast to those obtained with (CBA X …

Cytotoxicity ImmunologicGenotypeT-LymphocytesvirusesImmunologychemical and pharmacologic phenomenaVirusMajor Histocompatibility ComplexEpitopesMiceGenotypeAnimalsLymphocytic choriomeningitis virusSimplexvirusImmunology and AllergyCytotoxic T cellGeneMice Inbred BALB CParamyxoviridae InfectionsbiologyHerpes Simplexbiology.organism_classificationVirologySendai virusParainfluenza Virus 1 HumanMice Inbred C57BLCTL*RickettsiaLytic cycleMice Inbred CBAEuropean Journal of Immunology
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T-T cell interactions during in vitro cytotoxic T lymphocyte responses. III. Antigen-specific T helper cells release nonspecific mediator(s) able to …

1980

T helper cell induction and the specificity of T cell-mediated help as generated during alloreactive and H-2-restricted, virus- or hapten-specific cytotoxic T lymphocyte (CTL) responses have been compared. With the use of a double-chamber culture system, it was possible to dissect and separately analyze the induction phase of T helper cells from the T helper cell effector function. The data obtained revealed that during alloreactive as well as H-2-restricted T cell responses, antigen-specific T helper cells are induced. Upon specific restimulation of T helper cells, helper cell function is mediated across a cell-impermeable membrane via soluble products in an apparently nonspecific and nonr…

Cytotoxicity ImmunologicIsoantigensCell Membrane PermeabilityT cellT-LymphocytesImmunologyCellLymphocyte CooperationStreptamerBiologyInterleukin 21EpitopesMicemedicineImmunology and AllergyCytotoxic T cellAnimalsAntigen-presenting cellMice Inbred BALB CH-2 AntigensT helper cellCell biologyParainfluenza Virus 1 HumanMice Inbred C57BLCTL*medicine.anatomical_structureSolubilityTrinitrobenzenesMice Inbred CBAEuropean journal of immunology
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Virion Antigens Introduced Exogeneously into the Cell Membrane Render Syngeneic Target Cells Susceptible for T Cell-Mediated Cytolysis

1977

Non-infectious sendai virus renders H-2 matched target cells susceptible to the lytic effect of sendai virus immune cytotoxic T lymphocytes. This observation suggests that exogeneous insertion of virion antigen in the membrane of the target cell is sufficient for T cell cytotoxicity. The finding is incompatible with the concept that H-2K or H-2D gene products of the target cells must be altered in their primary structure (pretranslational effect of the virus infection) for T cell-mediated cytolysis to occur.

Cytotoxicity ImmunologicMacrophagesT-LymphocytesvirusesGeneral MedicineBiologybiology.organism_classificationMolecular biologyVirusSendai virusParainfluenza Virus 1 HumanCell membraneMiceCytolysismedicine.anatomical_structureImmune systemAntigenLytic cycleAntibody SpecificityHistocompatibility AntigensMice Inbred CBAmedicineAnimalsCytotoxic T cellAntigens ViralZeitschrift für Immunitätsforschung: Immunobiology
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T cell-mediated cytotoxic immune responsiveness of chimeric mice bearing a thymus graft fully allogeneic to the graft of lymphoid stem cells

1980

Fully allogeneic, chimeric mice were established by adult thymectomy of (A × B) F1animals, grafting parental A-type thymus under the kidney capsula, followed by lethal (900 rd) irradiation and reconstitution with B parental-type bone marrow cells treated with xenogeneic anti-T cell antiserum plus complement. Following in vivo sensitization with inactivated Sendai virus (SV) suspensions, no virus-specific T cells could be detected within the spleen cells of the mice. Upon stimulation with third-party allogeneic cells in a primary mixed lymphocyte culture, spleen cells of all animals generated alloreactive cytotoxic T lymphocytes (CTL). More interestingly, upon secondary in vitro stimulation …

Cytotoxicity ImmunologicT-LymphocytesT cellImmunologySpleenThymus GlandBiologyMiceImmune systemBone MarrowmedicineAnimalsImmunology and AllergyCytotoxic T cellLymphocytesMice Inbred BALB CChimeraMolecular biologyParainfluenza Virus 1 HumanMice Inbred C57BLCTL*medicine.anatomical_structureRadiation ChimeraImmunologyMice Inbred CBALymphoid Progenitor CellsBone marrowStem cellEuropean Journal of Immunology
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Homologous recombination as a mechanism of genetic changes in bovine parainfluenza-3 virus

2021

Bovine parainfluenza-3 virus (BPIV-3) is one of the main viruses associated with bovine respiratory disease complex (BRDC) worldwide. BPIV-3 infect the bovine respiratory tract causing from subclinical infections to severe pneumonia with significant economic losses in the cattle industry. BPIV-3 is a RNA virus with high genetic variability, nevertheless, the contribution of recombination events to its variability has not been assessed so far. In this study the 25 complete genome sequences (CGS) reported so far and 215 partial sequences of different viral genes of BPIV-3 were analyzed to determine their genotypes and subgenotypes, distribution, and the existence of potential recombination ev…

GenotypeCattle DiseasesSheep DiseasesBiologyRespirovirus InfectionsMicrobiologyGenomeVirusViral ProteinsAnimalsGenetic variabilityHomologous RecombinationGeneParainfluenza Virus 3 BovinePhylogenyGeneticsSheepGeneral VeterinaryPhylogenetic treeGenetic VariationRNA virusGeneral Medicinebiology.organism_classificationBovine Respiratory Disease ComplexCattleHomologous recombinationVeterinary Microbiology
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SARS CoV2 infection _The longevity study perspectives

2021

Graphical abstract

MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Seasonal Human Coronavirus Respiratory Tract Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

2021

Abstract Background Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT). Methods This was a collaborative Spanish and European bone marrow transplantation retrospective multicenter study, which included allo-HSCT recipients (adults and children) with upper respiratory tract disease (URTD) and/or lower respiratory tract disease (LRTD) caused by seasonal HCoV diagnosed through multiplex polymerase chain reaction assays from January 2012 to January 2019. Results We included 402 allo-HSCT recipients who developed 449 HCoV URTD/LRTD episodes. Median age of recipients was 46 years (range,…

PNEUMONIAMalevirusesmedicine.medical_treatmentseasonal human coronavirusHematopoietic stem cell transplantationmedicine.disease_causeDISEASElaw.inventionCoronavirus OC43 HumanCLINICAL CHARACTERISTICSlawCoronavirus 229E HumanRisk FactorsImmunology and AllergyChildRespiratory Tract InfectionsNL63 INFECTIONSCoronavirusOUTCOMESRespiratory tract infectionsSYNCYTIAL VIRUSHazard ratioHematopoietic Stem Cell Transplantationvirus diseasesupper and lower respiratory tract diseaseHCoV-NL63HCoV-229Erespiratory systemMiddle AgedIntensive care unitHospitalizationimmunocompromisedsurgical procedures operativeInfectious Diseasesmedicine.anatomical_structureAcademicSubjects/MED00290Child PreschoolCohortFemaleSeasonsCoronavirus InfectionsRare cancers Radboud Institute for Health Sciences [Radboudumc 9]allogeneic hematopoietic stem cell transplantation; community-acquired respiratory virus; HCoV-229E; HCoV-HKU1; HCoV-NL63; HCoV-OC43; immunocompromised; immunodeficiency score index; multiplex PCR assay; seasonal human coronavirus; upper and lower respiratory tract diseaseAdultmedicine.medical_specialtyHCoV-OC43AdolescentDIAGNOSISCHINAHCoV-HKU1BetacoronavirusAll institutes and research themes of the Radboud University Medical Centerstomatognathic systemInternal medicinemedicineMajor ArticleRHINOVIRUSHumansallogeneic hematopoietic stem cell transplantationAgedRetrospective Studiescommunity-acquired respiratory virusbusiness.industryInfantmultiplex PCR assayTransplantationCoronavirus NL63 HumanPARAINFLUENZA VIRUSbusinessimmunodeficiency score indexRespiratory tract
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The clinical benefit of instituting a prospective clinical community-acquired respiratory virus surveillance program in allogeneic hematopoietic stem…

2019

Highlights • Rapid detection methods used as first diagnostic test for CARVs may delayed the start of antiviral therapy in a significant number of influenza and RSV cases. • Syndromic multiplex RT-PCR-based prospective clinical CARV survey in allo-HCT recipients translates into a lower mortality rate as compared to standard clinical practice based on RSV and influenza virus rapid detection test. • We found that donor/recipient HLA mismatch, CARV LRTD and high-risk ISI were also associated with higher mortality.

Prospective respiratory virus surveillance program0301 basic medicineMicrobiology (medical)medicine.medical_specialtymedicine.medical_treatment030106 microbiologyHematopoietic stem cell transplantationRespiratory syncytial virusArticleParainfluenza virus03 medical and health sciences0302 clinical medicineStudy reportCommunity-acquired respiratory virusInternal medicinemedicineHumansProspective Studies030212 general & internal medicineStage (cooking)Prospective cohort studyRespiratory Tract InfectionsRetrospective Studiesbusiness.industryHematopoietic Stem Cell TransplantationRetrospective cohort studyInfluenzaInfectious Diseasesmedicine.anatomical_structureRespiratory virus infectionVirusesAllogeneic hematopoietic stem cell transplantationRespiratory virusbusinessLower mortalityImmunodeficiency score indexRespiratory tractJournal of Infection
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Shared determinants between virus-infected and trinitrophenyl-conjugated H-2-identical target cells detected in cell-mediated lympholysis

1976

Infection of H-2-identical mice with either lymphocytic choriomeningitis (LCM) virus, vaccinia virus, or paramyxo (Sendai) virus resulted in the generation of specifically sensitized cytotoxic T lymphocytes (CTL). CTL generated in vitro against 2,4,6-trinitrophenyl (TNP)-conjugated syngeneic stimulator cells were specifically cytotoxic for TNP-conjugated H-2K (D) region identical targets. Both LCM and vaccinia-induced CTL, however, were found to be strongly cytotoxic towards TNP-conjugated, H-2K(D) region-identical target cells. In contrast, Sendai virus-induced CTL did not lyse TNP-conjugated, syngeneic target cells. Inhibition experiments using cold targets suggested that shared antigenic…

T-LymphocytesvirusesImmunologyMice Inbred StrainsVaccinia viruschemical and pharmacologic phenomenaCross ReactionsBiologyLymphocytic choriomeningitisVirusEpitopeEpitopesMicechemistry.chemical_compoundAntigenHistocompatibility AntigensmedicineAnimalsLymphocytic choriomeningitis virusImmunology and AllergyCytotoxic T cellCells CulturedNitrobenzeneshemic and immune systemsCytotoxicity Tests Immunologicmedicine.diseaseVirologyIn vitroParainfluenza Virus 1 HumanCold TemperatureCTL*chemistryTrinitrobenzenesVacciniaEuropean Journal of Immunology
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